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Such studies support the rationale for testing GHR antagonism in cancer, but only a small number of preclinical studies have used pegvisomant in an oncology setting

Preclinical rodent studies support effects on angiogenesis, endothelial function, and nitric-oxide-related signaling, though these effects are reproducible in animals but not yet validated in humans

doi: 10.1093/mmy/myy027 320 PiresR